Why does paxil often not work the second time around?

Bilo76 · 05-30-2012, 05:59 PM

Anyone ever seen any research on it? Or perhaps someone has any logic idea why paxil often doesnt work second time around? Paxil has the name to be worse on this area then other ssris. Is it even true? Or is paxil simply older and therefor more experiences with it.?
And do "they" mean reinstation after a poopout or any second time at all.
Anyone knows? Or any guess is welcome. Its one of those things people repeat after eachoter on this forum and i wonder on what its based.
Just like many others i did a quick taper. And i do want to get off these drugs but perhaps i need to do a reinstate and then a slow taper. So this subject is of interest to me.

Backtopaxil · 05-30-2012, 06:48 PM

I have been myslef asking this question for months.

It worked so beautifully the first time around. I weaned in six weeks, from 10mg, then reinstated 10 days after my last dose and was slammed with physical symptoms overnight, yes overnight. And those never subsided. Tried Zoloft, then tried Paxil 10mg once again, then 20mg. Magic was over.

For me it just never worked as before. Or I may have hit poop-out. Seems to be a one time wonder for some of us.

aberdeen · 05-30-2012, 07:20 PM

Can't think of who, but I have read where some people are fine with going back on. Depends on the person I guess.

Backtopaxil · 05-30-2012, 07:33 PM

From www.crazymeds.us

5.3 Interesting stuff your doctor probably didn’t tell you

Paxil one of those meds that if you stop taking it and start up again, it won’t work as well as it used to. For some people that includes stopping for just a couple of days, experiencing the hell of SSRI discontinuation syndrome, and then going back on Paxil. You have to be totally med compliant with Paxil or it could be a pointless waste of time, money and suffering.
Paxil is less likely to work / doesn’t work as well for post-menopausal women. Which just figures, because it’s also pregnancy category D.
More of Paxil pros, cons, and interesting stuff

scotty · 05-30-2012, 07:58 PM

Quote:

Originally Posted by Bilo76

Anyone ever seen any research on it? Or perhaps someone has any logic idea why paxil often doesnt work second time around? Paxil has the name to be worse on this area then other ssris. Is it even true? Or is paxil simply older and therefor more experiences with it.?
And do "they" mean reinstation after a poopout or any second time at all.
Anyone knows? Or any guess is welcome. Its one of those things people repeat after eachoter on this forum and i wonder on what its based.
Just like many others i did a quick taper. And i do want to get off these drugs but perhaps i need to do a reinstate and then a slow taper. So this subject is of interest to me.

Well, research(official stuff) is non existent. The "guess" is that once the brain wears out from years of paxil use, it just doesn't make the changes that the initial use made. It is speculated that the initial "good" feelings that paxil creates is due to a low level adrenalin release, which will stop after a period of time. On a restart you're not starting with a clean slate, you're starting with a brain that has been altered in the past and may not be so predictable in it's response to the same drug.

Just speculation, but something we see all the time with those who attempt to restart.

mapleleafgirl25 · 05-31-2012, 07:39 AM

i have gone back on 2x and have been fine both times...i had been off the meds for almost a year each time..it must depend on the person..but i will say..it was never the same as the first time i was on it..

Bilo76 · 05-31-2012, 08:31 AM

Quote:

Originally Posted by scotty

Well, research(official stuff) is non existent. The "guess" is that once the brain wears out from years of paxil use, it just doesn't make the changes that the initial use made. It is speculated that the initial "good" feelings that paxil creates is due to a low level adrenalin release, which will stop after a period of time. On a restart you're not starting with a clean slate, you're starting with a brain that has been altered in the past and may not be so predictable in it's response to the same drug.

Just speculation, but something we see all the time with those who attempt to restart.

But whats the difference between paxil and other ssris, scotty? That low level adrenalin kick? Cause i read everywhere that paxil is different and other ssris have much better chance of working again.

scotty · 05-31-2012, 10:09 AM

Quote:

Originally Posted by Bilo76

But whats the difference between paxil and other ssris, scotty? That low level adrenalin kick? Cause i read everywhere that paxil is different and other ssris have much better chance of working again.

In my experience they are all a problem on a restart, not just paxil.

jr1985 · 05-31-2012, 10:25 AM

I read an interesting analogy - your brain on AD's is like a plant growing on a trellis. If you yank the trellis (the drug) out, the plant (your brain) will be disrupted. You can shove the trellis back in but the plant won't be the same. Although, it can help support the plant as it repairs itself.

Luckily your brain can repair itself, just like the plant.

Mantaray · 05-31-2012, 11:37 AM

In one of my previous attempts to get off SSRI's i half buttedly tapered Celexa. When I tried to go back on it 6 monthsl later it was disasterous.
I was always able to run back to Paxil accept the last time. It rejected me big time..

Bilo76 · 05-31-2012, 12:13 PM

Quote:

Originally Posted by Mantaray

In one of my previous attempts to get off SSRI's i half buttedly tapered Celexa. When I tried to go back on it 6 monthsl later it was disasterous.
I was always able to run back to Paxil accept the last time. It rejected me big time..

What was disastrous? What symptoms did you have?
I always wonder about that. i mean; i am in a hell that i barely can leave the house. Panic attacks/anxiety/ burning nerves/weird thoughts/Dp/DR/ obsessive thinking/suicidal/dizziness and so many weird feelings about what i am.

I mean how can this get any worse? So i wonder how it got worse for you

aberdeen · 05-31-2012, 04:33 PM

Love the trellis analogy. A plant will always find a new way to grow, taking the trellis away didn't kill it.

Massive · 05-31-2012, 05:19 PM

I been back on 3 times, slightly less effective each time.

Bilo76 · 05-31-2012, 05:30 PM

The question for me is: does paxil still work after a poopout? If i read into what doctors say, some say that it will work again if you had a different ad in between, seems to rewire the synaps. Some say it will work again if you have been off for at least 6 months. Some say yes but only in higher dose. And some say no it wont work.
Well isnt that a clear answer. Pff hate this drug

rose32 · 05-31-2012, 07:04 PM

Bilo

I was in poop-out, I had no clue but it was poop-out big time and paxil helped me.

I was on prozac then paxil, then for a whie ( when paxil was not available to me) zoloft then back to paxil sometimes long spans of time between. In the end when I did want to taper... I did and I am better for doing a slow taper. I am no scientist but in my opinion I would go back to paxil and get stable and slow taper.

Experience sometimes is the best teacher ....
Most dr have never taken this drug and have no experience with it in that way, we here have. I hope you can see the that

Rose

05-30-2012, 05:59 PM	#1
Bilo76 Join Date: Oct 2011 Location: Holland Posts: 1,641	Why does paxil often not work the second time around? Anyone ever seen any research on it? Or perhaps someone has any logic idea why paxil often doesnt work second time around? Paxil has the name to be worse on this area then other ssris. Is it even true? Or is paxil simply older and therefor more experiences with it.? And do "they" mean reinstation after a poopout or any second time at all. Anyone knows? Or any guess is welcome. Its one of those things people repeat after eachoter on this forum and i wonder on what its based. Just like many others i did a quick taper. And i do want to get off these drugs but perhaps i need to do a reinstate and then a slow taper. So this subject is of interest to me. __________________ Bilo aka Remco 14 years on Paxil 20 mg cause of a bad anxiety disorder (social anxiety, agoraphobia) 2011 Oct 16th: Cold turkey stop Paxil cause of poopout and switch to lexapro 15 mg. Hell started. Tapered lexapro. Tapered oxazepam. Med-free since may 18th 2012 "....We should take care not to make the intellect our god; it has, of course, powerful muscles, but no personality. It can not command, only serve..." Albert Einstein.

05-30-2012, 06:48 PM	#2
Backtopaxil Join Date: Dec 2011 Posts: 1,322	Re: Why does paxil often not work the second time around? I have been myslef asking this question for months. It worked so beautifully the first time around. I weaned in six weeks, from 10mg, then reinstated 10 days after my last dose and was slammed with physical symptoms overnight, yes overnight. And those never subsided. Tried Zoloft, then tried Paxil 10mg once again, then 20mg. Magic was over. For me it just never worked as before. Or I may have hit poop-out. Seems to be a one time wonder for some of us. __________________ Started April /03-Jul 30/11 10 mg Paxil 2nd Paxil Tapering Off as of May 28th, 12 "This will take time but it will happen!" "I've been shouting: it takes at LEAST a year " -- Ariella "If I am going to suffer, at least I will be Paxil free" -- me!

05-30-2012, 07:20 PM	#3
aberdeen Join Date: Jan 2012 Location: Canada Posts: 2,929	Re: Why does paxil often not work the second time around? Can't think of who, but I have read where some people are fine with going back on. Depends on the person I guess. __________________ *2 Timothy 1:7: "For God hath not given us the spirit of fear; but of power, and of love, and of a sound mind."* 2005-2010 Effexor XR 112.5mg-262.5mg for PPD Dec 2010 Poop-out and rapid 3 month wean. Off Effexor March 2011 Hell started 1 month later-tried 3 other meds to deal with w/d nothing worked. . Now tapering from 20mg Paxil (still recovering from Effexor w/d) Oct'11 to Nov '12 20mg-10mg Mar 5/13- 9mg Apr 12/13-8.1mg May 5/13-7.3mg

05-30-2012, 07:33 PM	#4
Backtopaxil Join Date: Dec 2011 Posts: 1,322	Re: Why does paxil often not work the second time around? From www.crazymeds.us 5.3 Interesting stuff your doctor probably didn’t tell you Paxil one of those meds that if you stop taking it and start up again, it won’t work as well as it used to. For some people that includes stopping for just a couple of days, experiencing the hell of SSRI discontinuation syndrome, and then going back on Paxil. You have to be totally med compliant with Paxil or it could be a pointless waste of time, money and suffering. Paxil is less likely to work / doesn’t work as well for post-menopausal women. Which just figures, because it’s also pregnancy category D. More of Paxil pros, cons, and interesting stuff __________________ Started April /03-Jul 30/11 10 mg Paxil 2nd Paxil Tapering Off as of May 28th, 12 "This will take time but it will happen!" "I've been shouting: it takes at LEAST a year " -- Ariella "If I am going to suffer, at least I will be Paxil free" -- me!

05-31-2012, 07:39 AM	#6
mapleleafgirl25 Join Date: Aug 2004 Location: Vancouver, Canada Posts: 2,638	Re: Why does paxil often not work the second time around? i have gone back on 2x and have been fine both times...i had been off the meds for almost a year each time..it must depend on the person..but i will say..it was never the same as the first time i was on it.. __________________ 3rd attempt at withdrawal going slow..compounded pills Taper: 05/27/2010 - 03/12/12: Tapered From 20mgs - 6.2 (2years) 04/11/2012 - 6.0 05/10/2012 - 5.8 06/09/2012 - 5.6 07/09/2012 - 5.4 80/08/2012 - 5.2 09/07/2012 - 5.0 10/07/2012 - 4.8 11/06/2012 - 4.6 12/06/2012 - 4.4 01/04/2013 - 4.2 02/03/2013 - 4.0 03/05/2013 - 3.8 04/04/2013 - 3.6 05/05/2013 - 3.4

05-31-2012, 10:25 AM	#9
jr1985 Join Date: Jan 2012 Posts: 442	Re: Why does paxil often not work the second time around? I read an interesting analogy - your brain on AD's is like a plant growing on a trellis. If you yank the trellis (the drug) out, the plant (your brain) will be disrupted. You can shove the trellis back in but the plant won't be the same. Although, it can help support the plant as it repairs itself. Luckily your brain can repair itself, just like the plant. __________________ 2003-2005: Paroxetine 2006-2009: Citalopram 2009-2011: Effexor Aug/Sept 11: Effexor -> Mirtazapine Oct: C/T Mirtazapine -> Effexor Nov/Dec: Fast Tapered Effexor - w/d hell 5/2/12: Reinstated Effexor 37.5mg 20/2/12: Updosed 75mg 9/3/12: Dropped 37.5mg 30/4/12: 33.8mg 1/5/12: 37.5mg 4/5/12: 35.6mg 19/6/12: Dropped 2.5% 23/6/12: 35.6mg 29/6/12: 37.5mg 30/6/12: 35.6mg 17/7/12: 37.5mg Yes, I know it's messy...

05-31-2012, 11:37 AM	#10
Mantaray Join Date: Sep 2011 Posts: 76	Re: Why does paxil often not work the second time around? In one of my previous attempts to get off SSRI's i half buttedly tapered Celexa. When I tried to go back on it 6 monthsl later it was disasterous. I was always able to run back to Paxil accept the last time. It rejected me big time.. __________________ Dec 2000 Paxil 20 MG for panic attacks 4 or 5 failed quits until December 2010 Poopout-Up to 30mg cross taper to zoloft 200mg March 2011 down to 100mg April 2011 cross taper to lexapro 10MG May 2011 August 2011 lexapro 7.5mg September 2011 lexapro 5mg February 2012 started taper, .5 mg every 3 weeks 05/18/12-06/07/12 2.5mg 06/07/12-06/30/12 2.0mg 06/30/12-07/10/12 1.5mg 07/10/12-08/08/2012 1.0mg 08/08/2012-08/19/2012 .5mg 8/20/2012 0 lexapro 15 mg of remeron to go

05-31-2012, 04:33 PM	#12
aberdeen Join Date: Jan 2012 Location: Canada Posts: 2,929	Re: Why does paxil often not work the second time around? Love the trellis analogy. A plant will always find a new way to grow, taking the trellis away didn't kill it. __________________ *2 Timothy 1:7: "For God hath not given us the spirit of fear; but of power, and of love, and of a sound mind."* 2005-2010 Effexor XR 112.5mg-262.5mg for PPD Dec 2010 Poop-out and rapid 3 month wean. Off Effexor March 2011 Hell started 1 month later-tried 3 other meds to deal with w/d nothing worked. . Now tapering from 20mg Paxil (still recovering from Effexor w/d) Oct'11 to Nov '12 20mg-10mg Mar 5/13- 9mg Apr 12/13-8.1mg May 5/13-7.3mg

05-31-2012, 05:19 PM	#13
Massive Join Date: Jan 2011 Posts: 180	Re: Why does paxil often not work the second time around? I been back on 3 times, slightly less effective each time. __________________ Seroxat 20mg 2007 - for depression resulting from undiagnosed arm pains November 2009 - Stopped st johns wort, started Paxil same day. Complete meltdown, no sleep for 2 weeks, extreme muscle pain, akathesia/anxiety 24/7. Lost everything, back on paxil and in work 3 months later. Mar 11 - 20 Aug 11 - 12.5 Dec 11 - 10 Mar 12 - 7.5 June 12 - 5 Sept 12 - 2.5 Oct 12 - 1.85 Oct/Nov 12 - 1.25 major crash Dec - updose 2.5 akathesia gone, extreme anxiety still.

05-31-2012, 05:30 PM	#14
Bilo76 Join Date: Oct 2011 Location: Holland Posts: 1,641	Re: Why does paxil often not work the second time around? The question for me is: does paxil still work after a poopout? If i read into what doctors say, some say that it will work again if you had a different ad in between, seems to rewire the synaps. Some say it will work again if you have been off for at least 6 months. Some say yes but only in higher dose. And some say no it wont work. Well isnt that a clear answer. Pff hate this drug __________________ Bilo aka Remco 14 years on Paxil 20 mg cause of a bad anxiety disorder (social anxiety, agoraphobia) 2011 Oct 16th: Cold turkey stop Paxil cause of poopout and switch to lexapro 15 mg. Hell started. Tapered lexapro. Tapered oxazepam. Med-free since may 18th 2012 "....We should take care not to make the intellect our god; it has, of course, powerful muscles, but no personality. It can not command, only serve..." Albert Einstein.

05-31-2012, 07:04 PM	#15
rose32 Join Date: Jun 2010 Location: CA Posts: 676	Re: Why does paxil often not work the second time around? Bilo I was in poop-out, I had no clue but it was poop-out big time and paxil helped me. I was on prozac then paxil, then for a whie ( when paxil was not available to me) zoloft then back to paxil sometimes long spans of time between. In the end when I did want to taper... I did and I am better for doing a slow taper. I am no scientist but in my opinion I would go back to paxil and get stable and slow taper. Experience sometimes is the best teacher .... Most dr have never taken this drug and have no experience with it in that way, we here have. I hope you can see the that Rose __________________ 1984-amitriptalene situational depression& anxiety 1989-1993-prozac 20-40MGS 2000-2010-zanax 1MGS-.5MGS 2011-.25MGS 2008-2012-provigil 200MGS ????-2012-lortab 10MGS PAXIL TAPER 2000-2012-paxil 40MGS 30-20,started taper 10/2010 10/2011-15--11/5/11-14--11/27/11-13 12/26/11-11.7--1/15/12-9.5--2/13/12-8.6 3/11/12-7.7mg--4/4/12-6.93--5-7/12--6.2mg-- 6/9/12--5.6mg--7-12-12--5.1mg--8-19-12--4.5mg 10/1/12--4.1mg--11/4/12--3.6mg--12-4-12--3.25-- 12/31/12-2.9--2/10/13-2.6 3/?/ 1.3-4/15 -0-

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