Choline decrease in SSRI withdrawal???

[FJ929]

Biol Psychiatry. 2003 Sep 1;54(5):534-9.

Selective serotonin reuptake inhibitor discontinuation syndrome is associated with a rostral anterior cingulate choline metabolite decrease: a proton magnetic resonance spectroscopic imaging study.

Kaufman MJ, Henry ME, Frederick B, Hennen J, Villafuerte RA, Stoddard EP, Schmidt ME, Cohen BM, Renshaw PF.
Source

Brain Imaging Center, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA.
Abstract

The selective serotonin reuptake inhibitor (SSRI) discontinuation syndrome (DS) is an important potential complication of treatment for major depression. We hypothesized that SSRI treatment discontinuation, resulting in change in clinical state, would be associated with reduced rostral anterior cingulate choline (Cho) metabolite ratios. Individuals with a DSM-III-R diagnosis of unipolar major depression who had been stabilized on paroxetine (n = 13) or fluoxetine (n = 13) were study subjects. They were monitored for change in clinical state (mood ratings, discontinuation symptoms) and underwent proton magnetic resonance spectroscopic imaging of the rostral anterior cingulate 3 days after medication substitution with active SSRI and placebo.Placebo-day Cho/Cre (choline/total creatine) metabolite ratios were decreased in four paroxetine and two fluoxetine subjects meeting DS criteria, as compared with asymptomatic subjects (Mann-Whitney z = -2.31, p =.021). Discontinuation syndrome is associated with a rostral anterior cingulate Cho/Cre metabolite ratio decrease that may reflect dynamics of rostral anterior cingulate function.

[IMISSME]

Originally Posted by FredJ

Biol Psychiatry. 2003 Sep 1;54(5):534-9.

Selective serotonin reuptake inhibitor discontinuation syndrome is associated with a rostral anterior cingulate choline metabolite decrease: a proton magnetic resonance spectroscopic imaging study.

Kaufman MJ, Henry ME, Frederick B, Hennen J, Villafuerte RA, Stoddard EP, Schmidt ME, Cohen BM, Renshaw PF.
Source

Brain Imaging Center, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA.
Abstract

The selective serotonin reuptake inhibitor (SSRI) discontinuation syndrome (DS) is an important potential complication of treatment for major depression. We hypothesized that SSRI treatment discontinuation, resulting in change in clinical state, would be associated with reduced rostral anterior cingulate choline (Cho) metabolite ratios. Individuals with a DSM-III-R diagnosis of unipolar major depression who had been stabilized on paroxetine (n = 13) or fluoxetine (n = 13) were study subjects. They were monitored for change in clinical state (mood ratings, discontinuation symptoms) and underwent proton magnetic resonance spectroscopic imaging of the rostral anterior cingulate 3 days after medication substitution with active SSRI and placebo.Placebo-day Cho/Cre (choline/total creatine) metabolite ratios were decreased in four paroxetine and two fluoxetine subjects meeting DS criteria, as compared with asymptomatic subjects (Mann-Whitney z = -2.31, p =.021). Discontinuation syndrome is associated with a rostral anterior cingulate Cho/Cre metabolite ratio decrease that may reflect dynamics of rostral anterior cingulate function.

Que?

[FJ929]

Originally Posted by IMISSME

Que?

LOL that's what I'm saying. I believe there stating that the choline to creatine ratio is reduced so I'm assuming this means low levels of Choline. I have faith in this study since they did imaging techniques and it was performed at Harvard University.

I really wish more of these studies were taking place it would really help those of us who are suffering with knowing what to take to help alleviate some symptoms.

[FJ929]

Choline is also know to affect the Dopamine whose dysfunction after ssri withdrawal is the prime suspect in anhedonia and PSSD.

[Backtopaxil]

But Paxil is anti-cholinergic per se, though not as potent as TCAs.

So once you remove the anti factor, would it make sense that choline would should shoot all the up?

The fact is that these drugs mess our entire neurotrasmission which is very delicate per se ( even some antibiotics can screw up the whole system..)

[scotty]

This is a 9 year old study that is "hypothesis". bottom line...no drug fixes what these drugs create.

[FJ929]

Originally Posted by Backtopaxil

But Paxil is anti-cholinergic per se, though not as potent as TCAs.

So once you remove the anti factor, would it make sense that choline would should shoot all the up?

The fact is that these drugs mess our entire neurotrasmission which is very delicate per se ( even some antibiotics can screw up the whole system..)

Who knows the complexity of the human Brain the way these neuros work with each other leads me to believe it would be more complex.