short timer

acornicus · 01-09-2006, 09:02 AM

I have talked with two other people that were not able too tolerate
paxil and had bad/severe reaction and experienced bad withdrawlas. One of the individuals works with my wife was on it less than a month (a short timer like me). Is this stuff about the p 450 enzyme well researched? I found a link on PP regarding this topic but it was there was too much medical terminology. Can anyone break this down for me? and what % of the general populous falls into this clasification? The problem with someone that doesn't
tolerate this med is after you have taken it for a couple days/week and you feel awful you call your doc and he/she tells you too just continue and that those "reactions" are typical. I sometimes think that instead of
paxil I must of somehow have ingested LSD!!! I know some of the you prolonged users may read this and say what's he complaining about. I have
thought that myself many times. I am 40 and had never taken any SSRI's
b4 this experience.I was a very active happy person who got overstressed and when I went too my Doc for a check she whipped out the old pen and wrote me a prescription faster than you could say paxil. I HAVE NOT BEEN THE SAME SINCE!!

Thanks for your help PP

Acorn

stevenwm · 01-09-2006, 09:26 AM

Acorn.

You may be allergic to SSRI`s especially Paroxitine?

I think everyone is allergic to them because when they try to wean off the drug they get deathly sick.Some get more sick than others.

Good luck to you and health.

Steven.

rdjanis · 01-09-2006, 09:32 AM

Some members have complained in the beginning such as you have, others down the road. Bottom line is the drug is nasty

I am not able to answer your question about the p 450 enzyme, but I am sure that others will kick in here shortly.

scotty · 01-09-2006, 09:50 AM

Acorn, The P450/2D6 enzyme pathway is a series of chemical reactions that happen in the liver to clear the blood and body of chemicals/drugs. It has been discovered that not everyone is created equal when it comes to this function.
They have divided the general population into 4 categories.

Poor metabolizers= 10% of the population
Intermediate Metabolizers= 35%
Extensive metabolizers=48%
Ultra metabolizers = 7%

Intermediate and Extensive metabolizers will probably never have a problem with getting rid of a drug in their system.

Poor metabolizers would need lower doses and will be more prone to toxic reactions at what would be considered "normal" doses of drugs.

Ultra metabolizers would need higher doses to achieve a therapeutic reaction

Now the unknown comes with ssri's and some other drugs is that they can "cause" this pathway to slow. So while you may be an extensive metabolizer when you start taking paxil over time you may become a poor metabolizer.

Alot of antibiotics are also "cleared" using this pathway, so this may account for the reactions that some have to antibiotics after being on paxil for a while, when they never had a problem in the past.

Hope this helps.

acornicus · 01-09-2006, 12:29 PM

Thanks Laurie that did help. If I am a slow metabolizer than the drug would build up in the blood stream and cause a toxic reaction? I really don't tolerate drugs well in general, never have. I had a ruptured appendix about ten years ago and the docs had me on some heavy duty antibiotics on an
IV. I was very ill and had terribly blurred vision durning my 9 day recovery. The docs just thought it was part of the recovery but as soon as I was taken off the antibiotics eveything returned to normal. Maybe I don't metabolize
meds well? Is there a test I can have done too determine if I am a slow metabolizer?

Thanks for all the help Laurie!!

Acorn

Charlie · 01-09-2006, 01:26 PM

There is suposed to be a test and I believe it was reported on by the Mayo Clinic. I have the info somewhere if I can find it.

scotty · 01-09-2006, 04:23 PM

The test is available at

www.genelex.com

acornicus · 01-09-2006, 05:22 PM

Thanks again Laurie...

Acorn

scotty · 01-09-2006, 06:55 PM

Anytime!

I believe that there are quite a few insurance companies that are now covering this test. You can contact Genelex and they will work with your insurance company on getting reimbursed.

Freddy88430 · 06-25-2008, 08:04 PM

Hello,

Is this CYP2D6 enzyme only responsible for "clearing" the drug out of your system? OR, is it ALSO responsible for breaking down the drug into its active (usable) metabolites too??
If not, then which enzymes are responsible for breaking down the drugs into their usable forms (metabolites)??

01-09-2006, 09:02 AM	#1
acornicus Join Date: Sep 2005 Location: Iowa GO HAWKS!! Posts: 174	short timer I have talked with two other people that were not able too tolerate paxil and had bad/severe reaction and experienced bad withdrawlas. One of the individuals works with my wife was on it less than a month (a short timer like me). Is this stuff about the p 450 enzyme well researched? I found a link on PP regarding this topic but it was there was too much medical terminology. Can anyone break this down for me? and what % of the general populous falls into this clasification? The problem with someone that doesn't tolerate this med is after you have taken it for a couple days/week and you feel awful you call your doc and he/she tells you too just continue and that those "reactions" are typical. I sometimes think that instead of paxil I must of somehow have ingested LSD!!! I know some of the you prolonged users may read this and say what's he complaining about. I have thought that myself many times. I am 40 and had never taken any SSRI's b4 this experience.I was a very active happy person who got overstressed and when I went too my Doc for a check she whipped out the old pen and wrote me a prescription faster than you could say paxil. I HAVE NOT BEEN THE SAME SINCE!! Thanks for your help PP Acorn

01-09-2006, 09:26 AM	#2
stevenwm Join Date: Dec 2005 Posts: 321	Re: short timer Acorn. You may be allergic to SSRI`s especially Paroxitine? I think everyone is allergic to them because when they try to wean off the drug they get deathly sick.Some get more sick than others. Good luck to you and health. Steven. __________________ Paxil Free Since 12/28/2005. Took 4 years 20mg for 1 year. 20mg twice daily roughly 3 years. Weaning route=Day. D.1- 17.5MG for 4 days. D.5-15MG for 3 days. D.8-10MG for 3 days. D.11-5MG for 2 days. D.13-0MG since 12/28/2005. Withdrawls YES!ZAPS-ect.Oh and I gained 65 pounds while on the poision. When I was a kid my parents moved a lot, but I always found them. Rodney Dangerfield

01-09-2006, 09:32 AM	#3
rdjanis "has a lavender scented keyboard" Join Date: Mar 2004 Location: Ontario Posts: 22,238	Re: short timer Some members have complained in the beginning such as you have, others down the road. Bottom line is the drug is nasty I am not able to answer your question about the p 450 enzyme, but I am sure that others will kick in here shortly. __________________ Rita

01-09-2006, 09:50 AM	#4
scotty Administrator & Advocate Join Date: Feb 2004 Location: new jersey Posts: 38,588	Re: short timer Acorn, The P450/2D6 enzyme pathway is a series of chemical reactions that happen in the liver to clear the blood and body of chemicals/drugs. It has been discovered that not everyone is created equal when it comes to this function. They have divided the general population into 4 categories. Poor metabolizers= 10% of the population Intermediate Metabolizers= 35% Extensive metabolizers=48% Ultra metabolizers = 7% Intermediate and Extensive metabolizers will probably never have a problem with getting rid of a drug in their system. Poor metabolizers would need lower doses and will be more prone to toxic reactions at what would be considered "normal" doses of drugs. Ultra metabolizers would need higher doses to achieve a therapeutic reaction Now the unknown comes with ssri's and some other drugs is that they can "cause" this pathway to slow. So while you may be an extensive metabolizer when you start taking paxil over time you may become a poor metabolizer. Alot of antibiotics are also "cleared" using this pathway, so this may account for the reactions that some have to antibiotics after being on paxil for a while, when they never had a problem in the past. Hope this helps. __________________ AKA Laurie "If you can find a path with no obstacles, it probably doesn't lead anywhere." ~Frank A. Clark

01-09-2006, 12:29 PM	#5
acornicus Join Date: Sep 2005 Location: Iowa GO HAWKS!! Posts: 174	Re: short timer Thanks Laurie that did help. If I am a slow metabolizer than the drug would build up in the blood stream and cause a toxic reaction? I really don't tolerate drugs well in general, never have. I had a ruptured appendix about ten years ago and the docs had me on some heavy duty antibiotics on an IV. I was very ill and had terribly blurred vision durning my 9 day recovery. The docs just thought it was part of the recovery but as soon as I was taken off the antibiotics eveything returned to normal. Maybe I don't metabolize meds well? Is there a test I can have done too determine if I am a slow metabolizer? Thanks for all the help Laurie!! Acorn

01-09-2006, 01:26 PM	#6
Charlie Join Date: Nov 2005 Posts: 7,561	Re: short timer There is suposed to be a test and I believe it was reported on by the Mayo Clinic. I have the info somewhere if I can find it. __________________ The truth is the truth even if no one believes it, and a lie is a lie even if everyone believes it." Knowledge speaks ....... Wisdom listens Charlie www.ThePaxilProtest.com

01-09-2006, 04:23 PM	#7
scotty Administrator & Advocate Join Date: Feb 2004 Location: new jersey Posts: 38,588	Re: short timer The test is available at www.genelex.com __________________ AKA Laurie "If you can find a path with no obstacles, it probably doesn't lead anywhere." ~Frank A. Clark

01-09-2006, 05:22 PM	#8
acornicus Join Date: Sep 2005 Location: Iowa GO HAWKS!! Posts: 174	Re: short timer Thanks again Laurie... Acorn

01-09-2006, 06:55 PM	#9
scotty Administrator & Advocate Join Date: Feb 2004 Location: new jersey Posts: 38,588	Re: short timer Anytime! I believe that there are quite a few insurance companies that are now covering this test. You can contact Genelex and they will work with your insurance company on getting reimbursed. __________________ AKA Laurie "If you can find a path with no obstacles, it probably doesn't lead anywhere." ~Frank A. Clark

06-25-2008, 08:04 PM	#10
Freddy88430 Join Date: May 2008 Location: New York, USA Posts: 61	Re: short timer Hello, Is this CYP2D6 enzyme only responsible for "clearing" the drug out of your system? OR, is it ALSO responsible for breaking down the drug into its active (usable) metabolites too?? If not, then which enzymes are responsible for breaking down the drugs into their usable forms (metabolites)??

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