|News / Research / Articles / Books Helpful resources for books, news, research and more. If you find a book article or research paper interesting, mention it here please.|
|03-22-2006, 08:07 PM||#1|
Join Date: Nov 2005
Location: chicago, illinois
and more propaganda
notice any particular drug not mentioned?
Study: Patients shouldn't give up on banishing depression
By Kathleen Fackelmann, USA TODAY
People with depression who don't get relief after taking one medication should switch or add another antidepressant, a study reports today.
"If the first drug doesn't work, don't give up," says John Rush, a psychiatrist at the University of Texas Southwestern Medical Center and the study's principal investigator.
Rush and his colleagues found that about 50% of people with depression could banish the blues with antidepressants, but some had to go to another drug or a drug combination to get relief.
The findings hold out hope for an estimated 15 million to 17 million Americans who have depression — especially those with a depression that doesn't go away.
"This is a devastating illness with enormous public health implications," says psychiatrist David Rubinow of the University of North Carolina-Chapel Hill.
Untreated depression contributes to more than 30,000 suicides in the USA each year and is the fourth-leading cause of disability, Rubinow says.
He wrote an editorial that accompanies the two articles describing the study results in today's New England Journal of Medicine.
But drugs aren't the only answer to depression, says Richard O'Connor, a therapist in private practice in New York and the author of two books on depression. O'Connor says a skilled therapist often can help people work through problems that can exacerbate or trigger a depression.
The National Institute of Mental Health, part of the National Institutes of Health, paid for the $35 million study, which was conducted at 41 primary care and psychiatric centers all over the USA.
In the first phase of this six-year study, patients, including those who had severe depression, were treated with a common antidepressant, Celexa, for up to 14 weeks. Patients who didn't get relief or who experienced too many side effects had the option of taking another common antidepressant or adding medications that combat depression in a different way.
In the first article, Rush and his colleagues report on results from 727 people who decided to switch from Celexa to one of three popular drugs that help fight depression: Zoloft, Effexor and Wellbutrin. About 25% of those people were free of any symptom of depression within 14 weeks of the switch, Rush says.
The study found no real differences between the drugs selected. Rubinow says that, in practice, this means that the doctor and patient might have to try several different kinds of drugs before they hit on one that works.
In the second article, the team reports on 565 people who decided to add on to their therapies. Those patients continued taking Celexa but also took either Wellbutrin or Buspar.
Within 14 weeks of getting the additional treatment, about 30% were symptom-free, Rush says.
Symptoms of depression include persistent sadness, fatigue, lack of interest in usually enjoyable activities and feelings of hopelessness.
It's important to keep pushing for relief with drugs — or talk therapy — or both, says Peter Kramer, a psychiatrist at Brown University in Providence and the author of the book Listening to Prozac.
"It's risky to let depression last a long time," he says.
|03-22-2006, 09:53 PM||#2|
Join Date: Feb 2004
Location: new jersey
Re: and more propaganda
So only 30% of those exposed to these toxic substances got "relief" with two drugs on board??? And psychiatry thinks this is a GOOD response? Now add in the 70% who will experience withdrawal.... real nice risk/benefit ratio there.
Can you imagine being given an antibiotic that only worked on 30% of the organisms it was supposed to kill... it would be off the market in a heartbeat!
Here's the definitive arrogance in this statement:
"It's important to keep pushing for relief with drugs
"Faith is taking the first step even when you don't see the whole staircase."
|03-22-2006, 11:37 PM||#3|
Join Date: Jul 2004
Location: Ontario, Canada
Re: and more propaganda
I've got an article that says that 78% of Effexor users experience withdrawl when tapering and off it.
I'm sure that clinical trials are just a farce. Ofcourse, the docs who are supposedly doing a "blind" study must notice the reactions and differences in people who are on placebo or on the real thing.
On A/D's since 1995, switching due to side-effects on 30 different brands of TCA's, SSRI's, SNRI's, Antipsychotics, Benzo's & Imovane. 6 ECT's. Tapering from 225 mg Effexor XR May 17, 2004. (Equiv. to 60 mg Paxil) Last taper Effexor XR Jan 17, 2006 down to ZERO. Currently protracted withdrawal. Sept 2006: 25 mg Doxepin. March 13/09: 10 mg Desipramine
|03-28-2006, 06:31 PM||#4|
Join Date: Aug 2005
Re: and more propaganda
Yes, but it's a great marketing tool to sell drugs from cradle to grave! If at first you don't suceed.....
The trouble is that it is easier to die on these drugs, even before any "results" happen to appear - if they ever do. Another great marketing tool - just convince people that they are not really polypharmaceutical consumers - it is just that multiple drugs are absolutely necessary for full and "optimal" recovery. If one drug doesn't do the trick, then just add another, and another, and another... and let's not forget we need other drugs to counteract the side-effects of the primary drugs. Why would any "thinking" person fall for this convoluted hypothesis to begin with? I thought these drugs- individually - were supposed to be smart enough to hit the "right" target immediately. I guess they are not so "smart" after all.