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Old 08-19-2006, 05:15 PM   #1
scotty's Avatar
Join Date: Feb 2004
Location: new jersey
Posts: 49,876
Zoloft and stroke victims

NEW YORK (Reuters Health) - In non-depressed patients who have
suffered a stroke, prophylactic treatment with Zoloft (also called
sertraline) does not prevent the onset of depression in the
following 6
months, according to results of a study.

Depression after stroke is common, affecting approximately 1 in
every 3
survivors, note Dr. Osvaldo P. Almeida and colleagues from the
University of Western Australia, Perth.

They examined whether Zoloft started within 2 weeks of a stroke and
continued for 24 weeks reduced the incidence of depression in 111
non-depressed stroke patients. Fifty-five stroke patients took Zoloft
(50 mg once daily) and 56 took a placebo.

The patients had a mean age of 67.5 years. Of the 111 subjects, seven
suffered hemorrhagic stroke caused by bleeding in the brain and 104
suffered ischemic stroke caused by a blockage.

"By the end of the 24-week trial, the proportion of participants who
were depressed was 21.6 percent (11/51) among patients assigned
and 16.7 percent (8/48 ) among those assigned sertraline," Dr.
team reports.

Overall, 29 patients (51.8 percent) in the placebo group and 26 (47.3
percent) in the sertraline group discontinued trial medication by
24. This was mostly due to perceived side effects or because
antidepressant medication was introduced.

"New pharmacologic and nonpharmacologic strategies need to be
developed," conclude the researchers, "to reduce the health and
financial burden associated with depression after stroke."

SOURCE: Journal of Clinical Psychiatry July 2006.
AKA Laurie

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Old 08-19-2006, 11:58 PM   #2
zappelina's Avatar
Join Date: Mar 2005
Location: Sweden
Posts: 2,387
Re: Zoloft and stroke victims

I canīt believe they gave an SSRI to people with hemorrhagic stroke, these drugs are blood thinners and can put them at risk for new strokes. What next?
AD history:
Celexa 20 mg 1997-98. Quit CT, no WD problems.
Paxil/Seroxat 20 mg 2001-2003 then switched to 50 mg Zoloft without any WD problems after the switch. Zoloft later increased to 75 mg.

2004 tapered Zoloft too quickly after sudden onset of muscle stiffness and extreme restlessness on full dose. Severe and prolonged WD problem with a long list of symptoms. Considerable mental but very little physical improvement so far. Last Zoloft dose April 18 2004.
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