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Adverse Drug Reaction Reporting    FDA Warnings    Published Withdrawal Studies    Pregnancy Warnings    Forum Psychology

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Old 08-19-2006, 04:15 PM   #1
scotty
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Zoloft and stroke victims

NEW YORK (Reuters Health) - In non-depressed patients who have
recently
suffered a stroke, prophylactic treatment with Zoloft (also called
sertraline) does not prevent the onset of depression in the
following 6
months, according to results of a study.

Depression after stroke is common, affecting approximately 1 in
every 3
survivors, note Dr. Osvaldo P. Almeida and colleagues from the
University of Western Australia, Perth.

They examined whether Zoloft started within 2 weeks of a stroke and
continued for 24 weeks reduced the incidence of depression in 111
non-depressed stroke patients. Fifty-five stroke patients took Zoloft
(50 mg once daily) and 56 took a placebo.

The patients had a mean age of 67.5 years. Of the 111 subjects, seven
suffered hemorrhagic stroke caused by bleeding in the brain and 104
suffered ischemic stroke caused by a blockage.

"By the end of the 24-week trial, the proportion of participants who
were depressed was 21.6 percent (11/51) among patients assigned
placebo
and 16.7 percent (8/48 ) among those assigned sertraline," Dr.
Almeida's
team reports.

Overall, 29 patients (51.8 percent) in the placebo group and 26 (47.3
percent) in the sertraline group discontinued trial medication by
week
24. This was mostly due to perceived side effects or because
antidepressant medication was introduced.

"New pharmacologic and nonpharmacologic strategies need to be
developed," conclude the researchers, "to reduce the health and
financial burden associated with depression after stroke."

SOURCE: Journal of Clinical Psychiatry July 2006.
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Old 08-19-2006, 10:58 PM   #2
zappelina
 
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Re: Zoloft and stroke victims

I canīt believe they gave an SSRI to people with hemorrhagic stroke, these drugs are blood thinners and can put them at risk for new strokes. What next?
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