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General Discussion Open discussion about Paxil, Paxil Withdrawal, successes and progress, good stories and bad, with and without.

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Old 01-17-2009, 11:29 PM   #1
Jeana
 
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Is 75 mg.s too high a dose for Paxil CR?

I have Dysthymia and Ocd. Dysthymia is the one I'm having problems with the most. My dr. raised my dose from 50mg to 75mg.s. Is that safe? I've been taking it without any problems but I was just curious.
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Old 01-17-2009, 11:47 PM   #2
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Re: Is 75 mg.s too high a dose for Paxil CR?

Well........ no problems if you dont count the dry mouth, weight gain, vivid dreams/nightmares, dissoriented feeling upon waking (every once in a while) that I've experienced before the increase in dosage. Oh, also the bad wd symptoms and worsening of my emotional/mental condition whenever I've tried tapering.
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Severe Depression/OCD since 94 lead to 1 suicide attempt in 96 which intoduced me to the wonderfull world of SRI's


Anafranil- Aprl 96 - June 96
Paxil 40mg.- June 96 - July 97
Luvox - July 97
Zoloft - Aug 97
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Old 01-17-2009, 11:58 PM   #3
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Re: Is 75 mg.s too high a dose for Paxil CR?

Although 75mg is HIGH, for ocd, it is recommended that one takes 60mg +. I only went up to 40mg for my OCD. I've been off paxil for almost a year and i find therapy and self help to be the most benfical
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Old 01-18-2009, 12:11 AM   #4
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Re: Is 75 mg.s too high a dose for Paxil CR?

The ocd is under control mostly through therapy, it's the chronic depression that neither the meds or therapy have been able to help much. If the dose I'm on now doesn't work my Dr. wants me to go back down to 50mg and try adding another med to boost the effect of paxil. If that does't work the next step is switching meds and from my past experiences doctors don't have much patience with slow tapering. That scares me because I've been through paxil w/d before, which is the main reason I agreed to the increase.
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Severe Depression/OCD since 94 lead to 1 suicide attempt in 96 which intoduced me to the wonderfull world of SRI's


Anafranil- Aprl 96 - June 96
Paxil 40mg.- June 96 - July 97
Luvox - July 97
Zoloft - Aug 97
Paxil 20mg.- Aug 97 - 2004
Paxil CR 37.5 mg. -2004 -2006?
Paxil CR 50mg. 2006? - Dec. 2008
Paxil CR 75 Mg. Dec 08 - present
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Old 01-18-2009, 12:42 AM   #5
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Re: Is 75 mg.s too high a dose for Paxil CR?

Quote:
Originally Posted by Jeana View Post
The ocd is under control mostly through therapy, it's the chronic depression that neither the meds or therapy have been able to help much. If the dose I'm on now doesn't work my Dr. wants me to go back down to 50mg and try adding another med to boost the effect of paxil. If that does't work the next step is switching meds and from my past experiences doctors don't have much patience with slow tapering. That scares me because I've been through paxil w/d before, which is the main reason I agreed to the increase.
If you switch meds, you would have to taper from 75g to 50mg or could you drop? I remmeber dropping from 40mg to 20mg and 20mg to 10mg. It was noticeable, but it wasnt unitl under 5mg that I felt horrilble.

You have to be firm wtih your doctors. My doc wanted me to drop from 10mg to zero because 10mg was the "lowest dosage" there was for Paxil. I told her there was a liquid and she said, no there arent liquids. I kept pressing and she looked it up and felt dumb lol.

I personally believe 75mg of paxil isway too high. Perhaps you could try another medication like your doc suggests but try not to take too much or else it would take a long time to get off. O and paxil is the worst with sides so I would much rather take another med
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Old 01-18-2009, 04:56 PM   #6
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Re: Is 75 mg.s too high a dose for Paxil CR?

From what I've read, anything over 60 mg is a toxic dose! Even 60 is very, very high and possibly that is a toxic level. (Others here know more about that and will likely join this discussion soon.)

I've also read here that going higher than a certain dose (sorry, I don't remember whether it was 60 or a lower dose) is not going to work - at least not for long.

I suspect you're either in what's known is poop-out (where the drug stops working, though you're still physically habituated [addicted] and need to do a very slow taper even if you're not getting desired benefits from the med) or having increasing dose tolerance, in which case you'll feel better initially from an increase in dose but then will have the same problems when your body adjusts to the new dose.

Have you ever tried the kind of slow taper that's advised by this group (not the schedule doctors call a "slow" taper!)? That means going down by a maximum of 10% of most recent dose every approx. 3-6 weeks when you start to feel stable on new dose? People in this group have a lot of experience with that very slow taper that seems to work best, and can guide you through doing it if your doctor won't or can't (most doctors are woefully unaware of the problems and best ways to get off these drugs).
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Old 01-18-2009, 05:31 PM   #7
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Re: Is 75 mg.s too high a dose for Paxil CR?

75mg is a toxic level of paxil. If they are attempting to increase to this level, then Paxil has pooped out. Paxil above 60mg(the maximum recommended dose) has not been shown to do anything positive.

What are your symptoms that you are calling "dysthymia and OCD"? Paxil is notorious for causing those symptoms.
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Old 01-18-2009, 06:04 PM   #8
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Re: Is 75 mg.s too high a dose for Paxil CR?

Dear Jeana,
I think you are taking Paxil CR and the posts above assume that you are taking regular Paxil.

If I understand correctly you are taking Paxil CR. For Paxil CR 75 mg is the maximum recommended dose.

75 mg of Paxil CR = 60 mg of regular Paxil.

You are at the maximum recommended dose.
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Old 01-18-2009, 06:10 PM   #9
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Re: Is 75 mg.s too high a dose for Paxil CR?

Quote:
Originally Posted by iwowi View Post
Dear Jeana,
I think you are taking Paxil CR and the posts above assume that you are taking regular Paxil.

If I understand correctly you are taking Paxil CR. For Paxil CR 75 mg is the maximum recommended dose.

75 mg of Paxil CR = 60 mg of regular Paxil.

You are at the maximum recommended dose.
Iwona is correct. 75 mgs of CR is the max dosage recommended by the manufacturer, which is still a very high dose. It sounds as though you've reached tolerance, which we refer to as "poop out." Going up in dose is only going to bring temporary relief which will mean you'll either have another drug added, or you'll be switched. Neither is a good option.
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Old 01-18-2009, 06:13 PM   #10
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Re: Is 75 mg.s too high a dose for Paxil CR?

Quote:
Originally Posted by iwowi View Post
Dear Jeana,
I think you are taking Paxil CR and the posts above assume that you are taking regular Paxil.

If I understand correctly you are taking Paxil CR. For Paxil CR 75 mg is the maximum recommended dose.

75 mg of Paxil CR = 60 mg of regular Paxil.

You are at the maximum recommended dose.
You are correct. The dosing is "diagnosis" specific. Paxil is not approved for OCD and below are the "recommended dosages" for depression.

From rxlist.com:

DOSAGE AND ADMINISTRATION
Major Depressive Disorder
Usual Initial Dosage: PAXIL CR should be administered as a single daily dose, usually in the morning, with or without food. The recommended initial dose is 25 mg/day. Patients were dosed in a range of 25 mg to 62.5 mg/day in the clinical trials demonstrating the effectiveness of PAXIL CR in the treatment of major depressive disorder. As with all drugs effective in the treatment of major depressive disorder, the full effect may be delayed. Some patients not responding to a 25-mg dose may benefit from dose increases, in 12.5-mg/day increments, up to a maximum of 62.5 mg/day. Dose changes should occur at intervals of at least 1 week.

So while 75 mg is the high end, it is above the recommended dosage for depression. Bottom line is a jump from 50mg to 75mg is treating poop out, not depression.
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Old 01-19-2009, 08:15 AM   #11
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Re: Is 75 mg.s too high a dose for Paxil CR?

Your signature says that you have been on Paxil for 12 years. This could easily explain your OCD and chronic depression. I had mild OCD before Paxil but it was magnified a thousand times while I was on it. I also never had depression or anxiety before Paxil and both hit really hard after I reached tolerance (poop-out). Have you considered tapering off of the Paxil and looking for other ways to deal with the OCD and depression?
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Old 01-19-2009, 03:28 PM   #12
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Re: Is 75 mg.s too high a dose for Paxil CR?

Quote:
Originally Posted by scotia21 View Post
Your signature says that you have been on Paxil for 12 years. This could easily explain your OCD and chronic depression. I had mild OCD before Paxil but it was magnified a thousand times while I was on it. I also never had depression or anxiety before Paxil and both hit really hard after I reached tolerance (poop-out). Have you considered tapering off of the Paxil and looking for other ways to deal with the OCD and depression?
I had similar experience. Paxil made me manic, OCD and caused me major anxiety and panic attacks. It all started around 4th year of being on Paxil when poop-out began. I never experienced any of those symptoms before going on Paxil. I never had depression before, during or after Paxil. I still wonder why I was put on an antidepressant.

It is also worth mentioning that many years of Paxil can also cause elevated cholesterol or blood pressure.
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PROZAC TAPER:
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Old 01-19-2009, 07:33 PM   #13
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Re: Is 75 mg.s too high a dose for Paxil CR?

there was a point in time when my dose was increased from 30mg to 40mg after complaining of increased anxiety and depression (this was after I had been on Paxil for about 7 years). Although I'm glad my doctor did not suggest another AD to add to the mix, the increase caused me to be a little manic or something. I just felt really out of sorts and behaving in ways I am not really proud of. This is when I decided to get off of this stuff. I'm so thankful that my psychologist helped me taper while writing my scripts whenever I needed a lower dose. I would think 75mg of Paxil would have put me in the grave. Looking back, I think the Paxil stopped working after about 3 years but I did not realize it. Good luck making a decision because eventually you will have to get off. Just remember to take it SLOW.
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Old 01-20-2009, 03:15 AM   #14
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Re: Is 75 mg.s too high a dose for Paxil CR?

75mg is very high i would not take that much but thats just me
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