Tramadol/Ultram and SSRIs

Pat Shields · 08-15-2009, 10:30 AM

If any of you take tramadol/Ultram or Ultracet, listen up!
http://www.hhsc.state.tx.us/HCF/vdp/.../tramadol.html

"Seizures have been reported in patients with predisposing factors receiving tramadol monotherapy at recommended doses as well as higher doses. The combined use of tramadol and either TCAs, SSRIs or neuroleptics may increase seizure risk in patients utilizing any of these drug combinations, as SSRIs inhibit tramadol metabolism, and TCAs, SSRIs, and neuroleptics reduce the tramadol seizure threshold. A warning has been included in the tramadol package insert describing this interaction. Additionally, concomitant administration of an SSRI with tramadol may result in serotonin syndrome due to additive blockage of serotonin reuptake. Several case reports have described the development of serotonin syndrome following the addition of tramadol to a stable SSRI treatment regimen. Symptoms of serotonin syndrome include irritability, altered consciousness, hyperthermia, increased muscle tone, rigidity, and coma. Serotonin syndrome may also lead to death. Concurrent administration of tramadol with either TCAs, SSRIs, or neuroleptics should be considered cautiously, if at all. Patients should be closely monitored for seizure activity as well as signs of serotonin syndrome."

GiannaK · 08-15-2009, 11:01 AM

Tramadol is bad news in any case...contrary to the hype they use to sell it as a non-narcotic pain reliever, IT IS addictive...

This is very important to know though. Thanks!

08-15-2009, 10:30 AM	#1
Pat Shields Ms. Pee Pee!! Join Date: Jan 2004 Location: St. Louis, Missouri area Posts: 5,789	Tramadol/Ultram and SSRIs If any of you take tramadol/Ultram or Ultracet, listen up! http://www.hhsc.state.tx.us/HCF/vdp/.../tramadol.html "Seizures have been reported in patients with predisposing factors receiving tramadol monotherapy at recommended doses as well as higher doses. The combined use of tramadol and either TCAs, SSRIs or neuroleptics may increase seizure risk in patients utilizing any of these drug combinations, as SSRIs inhibit tramadol metabolism, and TCAs, SSRIs, and neuroleptics reduce the tramadol seizure threshold. A warning has been included in the tramadol package insert describing this interaction. Additionally, concomitant administration of an SSRI with tramadol may result in serotonin syndrome due to additive blockage of serotonin reuptake. Several case reports have described the development of serotonin syndrome following the addition of tramadol to a stable SSRI treatment regimen. Symptoms of serotonin syndrome include irritability, altered consciousness, hyperthermia, increased muscle tone, rigidity, and coma. Serotonin syndrome may also lead to death. Concurrent administration of tramadol with either TCAs, SSRIs, or neuroleptics should be considered cautiously, if at all. Patients should be closely monitored for seizure activity as well as signs of serotonin syndrome." __________________ Patricia Paxil Fat (made May 27, 2006) http://www.youtube.com/watch?v=hbF48Ur4xtc No Paxil Fat(made May 20, 2007) http://www.youtube.com/watch?v=4qfvVVbSyJc Paxil Story Pt I(made June 2, 2007) http://www.youtube.com/watch?v=DINAdgszHfo Pt II(made July 15, 2007)http://www.youtube.com/watch?v=3bQnWeAWmDk Change your life by changing your thinking.

08-15-2009, 11:01 AM	#2
GiannaK Join Date: Jun 2009 Posts: 380	Re: Tramadol/Ultram and SSRIs Tramadol is bad news in any case...contrary to the hype they use to sell it as a non-narcotic pain reliever, IT IS addictive... This is very important to know though. Thanks! __________________ Beyond Meds http://bipolarblast.wordpress.com Drug free as of 2/09/10 recovery is slow

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