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Old 02-21-2010, 07:50 AM   #1
yabbadabba
 
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Half life of Zoloft

I have read that the half life of Zoloft is approx. 26 hours. I take one dose (currently at 125 and I'm slowly tapering off) at night. I also tend to get more nervous at night. Is this because I have only half the dose left in my body by the time I take the next dose?
Should I be taking half a dose in the morning and half in the evening? and if so, how would I possibly start this? And how would I taper with two separate doses a day?
Thank you so much!
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Old 02-21-2010, 07:57 AM   #2
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Re: Half life of Zoloft

It has half-life of 15 hours (zoloft). Paxil has 24.

Yes it is what I think too, try to take Zoloft in morning and evening split dose. It helped me really, with Effexor.
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Old 02-21-2010, 01:21 PM   #3
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Re: Half life of Zoloft

Hi Mixter! Thanks for replying.
How do I go about splitting the dose to two times a day for the first day? Would I just half what I take at night, then take the other half in the morning, and so on... wouldn't that seriously mess me up for the first few (or more) days until my body is more used to it?
How did you do it?
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Old 02-21-2010, 01:30 PM   #4
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Re: Half life of Zoloft

I looked again and several sites, including wikipedia and about.com say the half life of Zoloft "26 hours" or "about one day". I have heard Effexor is very hard to get off of because it has such a short half life.
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Old 02-21-2010, 01:52 PM   #5
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Re: Half life of Zoloft

No, Zoloft's half life is 26 hours. I don't recommend splitting doses on drugs with a half life of one day, it doesn't make much difference, since it's blood level which doesn't rapidly change with dosing changes.

100mg 24 hours later 50+100= 150 in the blood(this is very simplified)

50mg 12 hours later 25+50= 75 12 hours later 12.5+25+50 =87.5 in the blood so this doesn't achieve any additional stability.

You are essentially dropping your blood level by doing this.
These drugs are designed to be taken once a day, don't mess with the dosing schedule.

Effexor weaning is in a category all it's own. The same rules do not apply.
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Old 02-21-2010, 05:54 PM   #6
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Re: Half life of Zoloft

Thank you so much Scotty!
Wow, that is a relief- one less hurdle to think about overcoming.
Still a little confused about the half life:
So if I take, say, 100mg at night, by the next night I still have 50mg still in my bloodstream, and then I add another 100, making it 150mg, what keeps it from continuing to go up?

Thank you so much!
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Old 02-21-2010, 10:27 PM   #7
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Re: Half life of Zoloft

Quote:
Originally Posted by yabbadabba View Post
Thank you so much Scotty!
Wow, that is a relief- one less hurdle to think about overcoming.
Still a little confused about the half life:
So if I take, say, 100mg at night, by the next night I still have 50mg still in my bloodstream, and then I add another 100, making it 150mg, what keeps it from continuing to go up?

Thank you so much!
It reaches a steady level where you are just maintaining a constant level. Don't sweat the half life. Just keep weaning slow and steady and you're going to do fine.
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